Joseph Glenmullen, M.D.
See book keywords and concepts |  In a November 1998 expose on psychiatric drug testing in the Boston Globe, reporters Delores Kong and Robert Whitaker stated, "The companies need to get patients into their trials quickly, and they will pay researchers handsomely for doing so. But they also expect the researchers to deliver. Researchers who do not meet their patient quotas are not likely to get a contract for the next project."56
Indeed, Newell Unfried, vice president of a for-profit testing center called Alliance for Multispecialty Research, says, "The pressures are enormous. | | Because of the limited clinical testing that drugs receive before being marketed, in the early decades in which they are prescribed to patients every new psychiatric drug is an ongoing human experiment. As the more serious side effects of the Prozac group are more widely recognized, no doubt new drugs will emerge and be promoted as "safer." Indeed, a new, "improved" Prozac has already been announced.4 Chemicals like Prozac have two mirror-image forms—called right-Prozac and left-Prozac. The original version contains a mixture of the two. | | For example, in 1998 Minnesota psychiatrist Frank Abuzzahab was found guilty of "recklessly" entering patients into psychiatric drug studies, falsifying their records, and fabricating positive drug responses in an investigation by the Minnesota Board of Medical Practice. Said Dr. Morris Goldman, of the University of Chicago, who headed the investigation, "He would have the patient's diagnosis called one thing in the regular chart and then the person would be put on a drug study and the person's diagnosis would be called something else to fit the criteria. | | In an example involving a psychiatric drug, in the 1980s Upjohn pharmaceutical company sponsored a study in which its Valium-type antianxiety agent, Xanax, was compared to behavior therapy for the treatment of panic attacks. The study was conducted by a group of researchers headed by Dr. Isaac Marks in London—one of the world's leading authorities on behavioral treatment—and Dr. Richard Swinson in Toronto. Published in the British Journal of Psychiatry in 1993, the study found behavior therapy superior to the drug, especially in the long term. |
Textbook of Natural Medicine 2nd Edition Volume 1Michael T. Murray, ND
See book keywords and concepts | | Assessing the influence of the hospital milieu upon the effectiveness of psychiatric drug therapy. J Nerv Ment Dis 1963; 137: 143-154
162. Wheatly D. Influence of doctors' and patients' attitudes in the treatment of neurotic illness. Lancet 1967; ii: 1133-1135
163. Lewith GT. Every doctor a walking placebo. Comp Med Res 1987; 2: 10-18
164. Benson H, Epstein MD. The placebo effect. JAMA 1975; 232: 1225-1227
165. Brody HL. The lie that heals. Ann Int Med 1982; 97: 112-118
166. Jensen PS. The doctor-patient relationship. Headed for impasse or improvement? Ann Int Med 1981; 95: 769-771
167. |
Sheldon Saul Hendler
See book keywords and concepts |  In addition to phosphatidylcholine, two of the four patients received lithium (standard therapy for manic-depressive illness) and the other two, in addition to the phosphatidylcholine, received lithium and another psychiatric drug. All four patients improved. But when the phosphatidylcholine was withdrawn, manic symptoms reappeared in three of the four, even though they continued on the other medications.
In a later study, these researchers found that manic symptoms improved significantly more with phosphatidylcholine than with placebo in five of six patients treated. |
Stephen Fried
See book keywords and concepts |  Upjohn argued that spontaneous reports were unreliable, especially those of psychiatric side effects to a psychiatric drug, because drug reactions are so hard to separate from the underlying disease.
While this was going on, the U.K. approved Halcion, but only at lower doses: the one-quarter milligram and a one-eighth milligram. The drug was approved in the United States in 1982 at doses up to a half-milligram, over the objections of the FDA medical officer (who preferred only the lower doses approved, and also wanted patients to stop taking Halcion after two weeks). | | He told me about a new psychiatric drug, heading toward FDA approval, that he had tested on monkeys before it was given to humans. It had performed well, "with no nasty effects," on every test. And then, "out of the blue," he recalled, "I killed a monkey at a moderate dose. It died about five minutes after we gave it the drug."
What did that mean?
"Well, it's possible the drug has, in one in a hundred cases, a sudden toxic effect," he said. "The other possibility is that we injected the drug into the monkey's lungs by mistake instead of its gut. | | Because of Prozac's place in the psychiatric drug pantheon as the Pill of mental health, the study would also be seen as a windfall for its manufacturer, Eli Lilly. Koren found that ironic because Lilly hadn't been very interested in participating in the research and Prozac had only been added as a control drug. The study had primarily been funded by Ciba-Geigy to test one of its older tricyclic antidepressants.
Regardless of who paid and who benefited, the study was a landmark for pregnant women and for Motherisk. |
Joseph Glenmullen, M.D.
See book keywords and concepts | | Fava has been a particularly outspoken critic of psychiatric drug research that equates "health" with the suppression of symptoms instead of a higher expectation of well-being for patients. In his most recent research on treatment after initial improvement of depressive symptoms, Fava emphasizes lifestyle modifications and what he calls "well-being" therapy.26 Patients are informed that "depression is merely the consequence of a maladaptive lifestyle, which does not take life stress, interpersonal friction, excessive work, and inadequate rest into proper account. |
Ann Blake Tracy, Ph.D.
See book keywords and concepts | | How many patients realize the importance of providing their doctors with information about other medications they are using? How many realize that even mixing the over-the-counter medications with prescription drugs could cost them their lives? Dr. Jack Gorman, director of psychological studies at Columbia University's College of Physicians and Surgeons, made this statement to the writer of the WOMEN'S DAY article, "Even medications that don't usually cause problems, such as antibiotics, can produce psychiatric side effects in some individuals. | | For most people there are too many ifs. When one combines this information on drug interactions with the continued reports of Prozac causing an obsession for other chemicals which would cause a mixing of various mind altering substances, it becomes a very alarming and dangerous situation. |
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